Antiepileptic drugs (AEDs) have been
previously linked to suicidality. Primidone, an anticonvulsant commonly used to
treat essential tremor (ET), has been associated
with increased suicide risk in patients with seizures, which themselves
increase suicide risk.
However, an association with acute suicidality
in subjects without any predisposition has not been documented. We present a
case of acute suicidality following initiation of primidone for erroneously
diagnosed ET in a patient with Parkinson’s disease but no past psychiatric
history or risk factors.
Suicidal ideation quickly resolved after
primidone was discontinued. Patients receiving primidone should, therefore, be
carefully monitored after treatment initiation.
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